Modafinil in narcolepsy treatment

Modafinil use in modern clinical practice

Narcolepsy is a disease of nervous system, its main sign is attacks of sudden sleepiness. Factors, contributing to narcolepsy development is not always possible to determine. In some cases, narcolepsy develops due to previous infections (for example: malaria and epidemic encephalitis, and others). In other cases narcolepsy develops due to traumatic brain injury. In rare cases narcolepsy develops as hereditary factor.

Narcolepsy can be diagnosed according to three signs:
sleepiness attacks;
cataplectic attacks;
sleep disorder.

Short-term paralysis can occur in narcolepsy. Sleepiness attacks occur during the day in the form of sudden short sleep periods. Herewith, sleep can be of various depth. Such sleep is most often superficial and patients wake up duringĀ  insignificant noise or light touch. Favorable factors of sleepiness attack are: warm, cozy room; monotonous, sedentary work; tasty, square meal. During sleepiness attacks, reduction in muscle tonus and hallucinations attacks while falling asleep or awakening are observed.

Analeptics are prescribed to treat narcolepsy in modern clinical practice. Analeptics has a stimulating effect on central nervous system (CNS). Modafinil drug is the most effective and most commonly prescribed drug to treat narcolepsy.

Modafinil use in narcolepsy

When treating narcolepsy Modafinil effectively controls a sudden daytime sleepiness, hallucinations, cataplexy and sleep disorder. Modafinil is an alpha 1 adrenergic receptor agonist, increases dopamine release in the CNS, as well as the release of gamma-aminobutyric acid (GABA).

Modafinil is more effective than amphetamines as wakefulness stimulant. In contrast to amphetamines Modafinil is not habit-forming, does not cause euphoria, reduces peripheral excitement of CNS. Herewith, Modafinil almost does not affect blood pressure and does not cause depressed state after sleep.

Modafinil dosage in narcolepsy treatment

Modafinil medication is intended for oral administration. Modafinil tablets are recommended to take in the morning regardless of food intake.


Modafinil drug is prescribed in daily dosage of 200mg to suppress sleep and to preserve wakefulness.

Modafinil 200mg can be taken as a single dose or the dose can be divided into two intakes (one Modafinil 100mg pill in the morning and one Modafinil 100mg pill in the afternoon).

Maximum daily dose of Modafinil is 400mg. However, there are no statistical evidences that daily dose of Modafinil 400mg is more effective than daily dose Modafinil 200mg.

Modafinil daily dose is 100mg in elderly patients (over 65 years), as well as patients with kidney or liver dysfunctions.

Maximum daily dose of Modafinil is 200mg in elderly patients (over 65 years), as well as patients with kidney or liver dysfunctions.

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